Tag Archives: depression

Maternal Depression, But Not Exposure to SSRIs, Associated with Worse Executive Functioning in Children  

While we have considerable data on the use of selective serotonin reuptake inhibitors (SSRIs) during pregnancy, most of this research focuses on the risk of congenital malformations in exposed children.  We have far less information regarding the long-term effects of SSRI antidepressants on neurodevelopmental outcomes in exposed children. A recent study looks at executive functioning… Read More »

Oral Allopregnanolone Analogue for Postpartum Depression Treatment

In 2015, we first reported on SAGE-547 (SAGE Therapeutics), a new medication for the treatment of postpartum depression (PPD).  SAGE-547, now called brexanolone, is a neurosteroid, an analogue of allopregnanolone and an allosteric modulator of GABAA receptors.  Since that time, Sage Therapeutics has conducted three randomized controlled trials, enrolling a total of 247 women diagnosed… Read More »

Depression in New Moms Adversely Affects the Health of Babies and Other Family Members

Maternal depression experienced by half of expectant and new mothers go undiagnosed and untreated, which can lead to major long-term health problems both for parents and for their infants. In an effort to prevent such complications, a new report released by the American Academy of Pediatrics (AAP) is once again urging doctors to screen mothers… Read More »