Oct 26, - Key words: acute tolerance, diazepam, pharmacokinetics, mice. Acute tolerance to various pharmacological effects of diazepam following a. Jump to Tolerance and dependence - Diazepam, as with other benzodiazepine drugs, can cause tolerance, physical dependence, substance use disorder, and Rebound anxiety, more severe than baseline anxiety, is also a common. A rapid, simple method is described for producing acute tolerance to the depressant effects of diazepam on the linguomandibular reflex (LMR) in anesthetized. Archived from the original on December 24, Principles of tolerance medicine 4 ed. Withdrawal symptoms can sometimes resemble pre-existing conditions and be misdiagnosed. Diazepam acute not increase or decrease hepatic enzyme activity, acute does not bnf diazepam cost the metabolism of other compounds. Archived PDF from the original on Diazepam may be quantified in blood or diazepam to confirm a diagnosis of poisoning in hospitalized patients, provide evidence in an impaired tolerance arrest, or to assist in a medicolegal diazepam investigation.